In a tightly contested matchup, the San Francisco 49ers held off the Arizona Cardinals with a final score of 17-10, marking a crucial victory in Week 2 of the 2027 season. Both teams were looking to establish their identities early in the season, but it was the 49ers who came out on top in this defensive battle. Leading the charge for San Francisco was quarterback Anthony Richardson Sr, who showcased his dual-threat ability with 177 passing yards, one touchdown, and 50 rushing yards. He connected effectively with receiver Matthew Golden, who amassed 61 yards through the air, helping to keep the chains moving for the 49ers throughout the game. Defensively, San Francisco made their mark with a standout performance from Darnell Savage, who intercepted a pass to shift momentum in their favor. The game turned when the 49ers' defense stifled a late drive from the Cardinals, allowing only 10 points and forcing a critical turnover that sealed the victory. Meanwhile, the Cardinals' Caleb Ransaw led the way with three total tackles, but it wasn’t enough to overcome the defensive efforts of San Francisco.