In a decisive Week 3 matchup, the Arizona Cardinals topped the San Francisco 49ers with a commanding 33-13 victory, further establishing their dominance in the 2026 season. This win puts the Cardinals firmly on the map as a team to watch, showcasing their offensive firepower and strategic prowess. Josh Allen led the charge for Arizona, throwing for 284 yards and an impressive four touchdowns, demonstrating his ability to connect with his targets efficiently. Pat Freiermuth was Allen's top target, racking up 76 receiving yards and contributing significantly to the scoring. Meanwhile, Alvin Kamara provided a steady presence in the backfield, even if his rushing yards were limited to 29, adding to the team's overall offensive output. On the defensive side, the Cardinals made their mark with a stellar performance, highlighted by Kam Curl's two interceptions that swung momentum in their favor. The San Francisco defense, while solid at times, struggled to contain the Cardinals' explosive offense, with A.J. Terrell Jr. managing the only sack of the game. The turning point came when Curl's second interception led to a quick touchdown drive, effectively sealing the game for Arizona and leaving the 49ers searching for answers.