In a tightly contested matchup, the San Francisco 49ers emerged victorious over the Seattle Seahawks, securing a 17-7 win in Week 5 of the 2026 season. This victory not only bolsters the 49ers' standing in the division but also underscores their resilience against a familiar rival. Brock Purdy led the charge for San Francisco, throwing for 206 yards and two touchdowns, showcasing his ability to perform under pressure. Christian McCaffrey was a key target, racking up 65 receiving yards, while Joe Mixon paced the Seahawks on the ground with 45 rushing yards, struggling to find space against the stout 49ers' defense. Defensively, San Francisco took control of the game, highlighted by Dre Greenlaw's two crucial interceptions that shifted momentum in favor of the 49ers. Osa Odighizuwa contributed with a sack, applying consistent pressure on the Seahawks' offense. The turning point came late in the second quarter when Greenlaw's second interception set up a touchdown, allowing the 49ers to pull ahead and maintain control through the second half.