The Los Angeles Rams dominated the San Francisco 49ers with a final score of 38-3 in their Week 1 matchup of the 2026 season. This decisive victory sets a strong tone for the Rams as they look to build momentum early in the season while the 49ers will need to regroup after a tough start. Matthew Stafford led the Rams' charge, throwing for 140 yards and two touchdowns, showcasing his precision and poise under pressure. Kyren Williams was a standout on the ground, racking up 127 rushing yards and keeping the 49ers' defense on their heels. Puka Nacua also made his presence felt with 62 receiving yards, contributing to an offensive performance that was both explosive and efficient. Defensively, the Rams were formidable, limiting the 49ers to just three points. Kamren Kinchens anchored the unit with three total tackles, while the Rams' pressure forced the 49ers into tough situations throughout the game. The turning point came early when Stafford connected on a touchdown pass that shifted momentum firmly in favor of Los Angeles, leaving San Francisco struggling to recover.