In a thrilling shootout, the Detroit Lions narrowly defeated the Buffalo Bills 43-40 in Week 2 of the 2026 season. Both teams were looking to establish momentum early in the season, but it was the Lions who emerged victorious in this high-scoring affair. Josh Allen put on a dazzling performance for the Bills, throwing for 449 yards and four touchdowns, while James Cook III torched the Lions' secondary with 182 receiving yards. On the ground, Jahmyr Gibbs was a force for Detroit, racking up 153 rushing yards and contributing significantly to the Lions' offensive rhythm. Defensively, the Lions made key plays that turned the tide in their favor, highlighted by Jack Campbell's two interceptions. While Ed Oliver of the Bills recorded two sacks, it was Campbell's timely turnovers that shifted the momentum late in the game, allowing Detroit to hold off a feisty Buffalo comeback attempt and secure the win.