The San Francisco 49ers secured a decisive 45-27 victory over the Arizona Cardinals in Week 3 of the 2026 season, solidifying their position as a force in the NFC. With both teams looking to gain momentum early in the season, this win was crucial for the 49ers as they aim for a playoff push. Brock Purdy delivered an impressive performance under center for San Francisco, throwing for 296 yards and orchestrating a potent offense. Christian McCaffrey contributed effectively on the ground with 65 rushing yards, while the Cardinals' Jacoby Brissett kept pace with two touchdown passes, finding success through the air. Tyler Scott stood out for Arizona, racking up 100 receiving yards and showcasing his ability to stretch the field. Defensively, Malik Mustapha played a pivotal role for the 49ers, leading the team with five total tackles and snagging an interception that shifted momentum in San Francisco's favor. This critical turnover came at a key moment, allowing the 49ers to capitalize and extend their lead. The combination of a powerful offense and a timely defense ultimately sealed the victory, showcasing San Francisco's balanced attack and resilience.