The Arizona Cardinals secured a decisive 42-16 victory over the Detroit Lions in Week 5 of the 2026 season, solidifying their position as a formidable contender in the league. With this win, the Cardinals continue to assert their dominance, while the Lions seek answers following a tough loss. Quarterback Josh Allen led the charge for Arizona, throwing for 253 yards and four touchdowns, showcasing his elite passing ability. Derrick Henry contributed on the ground with 48 rushing yards, but it was Allen's aerial assault that truly set the tone. On the other side, Brian Thomas Jr. emerged as a bright spot for the Lions with an impressive 158 receiving yards, but it wasn't enough to keep pace with the Cardinals' offensive onslaught. Defensively, the Cardinals made timely plays that shifted momentum in their favor. Cor'Dale Flott's two interceptions proved critical in thwarting any potential Lions' comeback, while Azeez Al-Shaair's steady presence with four total tackles helped maintain control. The turning point came when Flott's second pick led to a quick touchdown, putting the Cardinals up 28-10, effectively sealing the game and showcasing their ability to capitalize on mistakes.