In a commanding performance, the Arizona Cardinals defeated the Washington Commanders 45-16 in Week 12 of the 2026 season. With playoff implications on the line, the Cardinals showcased their dominance, solidifying their position in the postseason race while the Commanders struggled to keep pace. Jacoby Brissett led the charge for Arizona, throwing for 263 yards and two touchdowns, while Tyler Allgeier added a strong ground game with 92 rushing yards. Michael Wilson emerged as Brissett's go-to target, racking up 101 receiving yards, making key catches that helped sustain drives and put points on the board. Defensively, the Cardinals were opportunistic, with Mack Wilson Sr. snagging an interception that turned the tide in the first half. Although the Commanders' Sonny Styles recorded nine tackles and Odafe Oweh had a sack, they were unable to contain the explosive Arizona offense. The turning point came when Wilson's interception led to a quick touchdown, shifting momentum firmly in favor of the Cardinals and sealing the deal for their decisive victory.