In a dominant display, the Buffalo Bills topped the Indianapolis Colts 38-7 in Week 4 of the 2027 season, solidifying their grip on the AFC. With this victory, the Bills continue to assert themselves as one of the premier teams in the league, while the Colts struggle to find their footing early in the season. Josh Allen was the standout performer for Buffalo, throwing for 169 yards and three touchdowns, showcasing his elite passing ability. Meanwhile, James Cook III added a strong ground game with 116 rushing yards, while Ian Strong contributed significantly with 70 receiving yards, making it a well-rounded offensive effort for the Bills. Buffalo's defense played a crucial role in the outcome, stifling the Colts' attack and forcing key turnovers. Greg Rousseau registered a sack, while Christian Benford intercepted a pass, helping to shift momentum in the Bills' favor. The turning point came early in the second half when Allen connected for a touchdown, extending their lead to 21-7 and effectively putting the game out of reach for Indianapolis.