In a dominant display, the Arizona Cardinals defeated the San Francisco 49ers 38-14 in Week 9 of the 2027 season. This crucial win keeps the Cardinals firmly in playoff contention while the 49ers struggle to find their footing in a competitive division. Arizona's offense was led by a stellar performance from running back Jeremy Dixon, who rushed for 131 yards and found the end zone, while wide receiver Justin Jefferson added a significant contribution with 132 receiving yards. Jaxson Dart of the 49ers managed to throw for 168 yards and a touchdown, but San Francisco's offense struggled to keep pace with Arizona's explosive attack. Defensively, the Cardinals made their mark with key plays that shifted momentum. Budda Baker recorded six tackles, while Yaya Diaby disrupted the 49ers' rhythm with 1.5 sacks. The turning point came when Jessie Bates III intercepted Dart in the second half, setting up a touchdown that put the game out of reach for San Francisco, sealing Arizona's commanding victory.