In a commanding performance, the San Francisco 49ers topped the Arizona Cardinals 42-20 in Week 3 of the 2026 season. With both teams seeking to establish dominance early in the year, the 49ers made a strong statement on their home turf, showcasing their offensive firepower and depth. Brock Purdy led the charge for San Francisco, throwing for 264 yards and four touchdowns, effectively orchestrating the offense throughout the game. Ricky Pearsall was a standout target, racking up 124 receiving yards, while Christian McCaffrey contributed significantly on the ground with 80 rushing yards, helping to keep the Cardinals' defense on its heels. Defensively, Nick Bosa anchored the 49ers with two total tackles and a sack, making his presence felt in critical moments. The turning point came midway through the second quarter when Purdy connected with Pearsall for a touchdown that shifted momentum firmly in favor of San Francisco, allowing them to control the game and ultimately secure the victory.