In a decisive Week 5 matchup, the Arizona Cardinals triumphed over the Detroit Lions with a final score of 28-10. The victory was crucial for the Cardinals as they continue to solidify their position in the playoff race during the 2026 season. Leading the charge for Arizona was quarterback Michael Penix Jr., who threw for 262 yards and two touchdowns, showcasing his ability to connect with receivers downfield. Michael Wilson was a standout in the passing game as well, racking up 75 receiving yards, while Jahmyr Gibbs led the Lions on the ground with 94 rushing yards, but it wasn’t enough to keep pace with the Cardinals' explosive offense. Defensively, Arizona applied consistent pressure, highlighted by Kenny Moore II's sack and Mack Wilson Sr.'s team-leading five tackles, which stifled Detroit's attempts to mount a comeback. The turning point came late in the second quarter when Penix Jr. connected on a crucial touchdown pass that extended the Cardinals' lead to 21-7, allowing them to control the game's tempo for the remainder.