In a dominant performance, the San Francisco 49ers topped the New York Giants 34-10 in Week 13 of the 2026 season. With playoff implications on the line, San Francisco solidified its position in the standings, while New York struggled to keep pace in a must-win game. Brock Purdy led the 49ers' air attack with 207 passing yards, while Christian McCaffrey showcased his elite running ability, racking up 125 rushing yards. De'Zhaun Stribling was a reliable target in the passing game, contributing 64 receiving yards. The 49ers' offense proved too much for the Giants to handle throughout the contest. On the defensive side, the game turned when Deommodore Lenoir snagged an interception, swinging momentum firmly in favor of San Francisco. Although the Giants' D.J. Reader recorded two sacks and Deonte Banks led the team with nine tackles, they were unable to stop the 49ers' relentless offensive assault. Ultimately, it was San Francisco's ability to capitalize on key defensive plays that secured their convincing victory.