In a decisive matchup, the Arizona Cardinals topped the Detroit Lions 42-18 in Week 5 of the 2026 season. With both teams looking to solidify their playoff positions, the Cardinals delivered a commanding performance that left no doubt about their dominance on the field. Jacoby Brissett was the star of the night, throwing for 281 yards and three touchdowns, connecting consistently with his receivers. Marvin Harrison Jr. was a standout target, racking up 148 receiving yards, while Jeremiyah Love showcased his skills on the ground with an impressive 144 rushing yards. Together, they fueled a potent offensive attack that overwhelmed the Lions' defense. On defense, the Cardinals were relentless, led by Darrell Baker Jr. with seven total tackles and Josh Sweat, who added a sack to the mix. The turning point came in the second quarter, when the Cardinals forced a critical turnover, allowing them to extend their lead and control the game. Although the Lions had some bright spots, including two interceptions from Kerby Joseph, they simply could not keep pace with Arizona's explosive offense.