In a tightly contested matchup, the San Francisco 49ers topped the Seattle Seahawks 21-10 in Week 12 of the 2026 season. The stakes were high as both teams aimed to solidify their playoff positioning, but it was the 49ers who managed to secure the win on their home turf. Brock Purdy led the 49ers with a steady performance, throwing for one touchdown and efficiently managing the game. Jalen Milroe of the Seahawks showcased his arm talent, racking up 256 passing yards, while Trey Benson contributed significantly on the ground with 107 rushing yards. Jaxon Smith-Njigba was the standout receiver for Seattle, finishing with 100 receiving yards, but it wasn’t enough to overcome San Francisco’s balanced attack. The 49ers' defense played a crucial role in the outcome, with Nick Bosa wreaking havoc in the backfield, recording 1.5 sacks. Deommodore Lenoir's interception proved to be a turning point, halting a potential scoring drive for the Seahawks and shifting momentum back to the 49ers. Seattle's defense was led by Drake Thomas, who tallied eight tackles, but ultimately, it was San Francisco's ability to capitalize on key defensive plays that sealed the victory.