In a thrilling Week 3 matchup, the San Francisco 49ers narrowly defeated the Arizona Cardinals with a final score of 42-38. Both teams entered the game looking to solidify their standings early in the season, but it was the 49ers who emerged victorious in a contest that showcased explosive offensive talent. Brock Purdy led the charge for San Francisco, throwing for 307 yards and four touchdowns, proving to be a formidable force in the pocket. Ricky Pearsall complemented Purdy's performance with an impressive 110 receiving yards, while the 49ers' balanced attack kept the Cardinals' defense on their heels throughout the game. On the ground, Arizona's Jeremiyah Love made his mark with 133 rushing yards, but it wasn't enough to overcome the 49ers' offensive firepower. Defensively, San Francisco made key plays that turned the tide in their favor. Deommodore Lenoir's six total tackles and Nick Bosa's sack were crucial in applying pressure on Arizona's offense, while Zaven Collins snagged an interception for the Cardinals, demonstrating the defensive battle that was waged. The turning point came in the fourth quarter when Purdy connected for a touchdown pass that put the 49ers ahead for good, sealing the victory and keeping their momentum going in the 2026 season.