In a commanding performance, the San Francisco 49ers triumphed over the Arizona Cardinals with a final score of 48-21 in Week 3 of the 2027 season. This victory not only solidifies the 49ers' early dominance but also sets the stage for a competitive season ahead as they assert themselves in the playoff race. Brock Purdy was the standout star for San Francisco, throwing for an impressive 503 yards and a staggering seven touchdowns. His connection with De'Zhaun Stribling was particularly lethal, as Stribling racked up 201 receiving yards, making big plays that kept the Cardinals' defense on its heels. Trey Benson contributed on the ground with 69 rushing yards, rounding out a potent offensive display. Defensively, the 49ers were just as effective, with Marques Sigle leading the charge with 10 total tackles. Shavon Revel Jr. made a critical interception that shifted momentum in the first half, ending a promising Cardinals drive and allowing San Francisco to capitalize with more points. The combination of offensive firepower and defensive resilience proved too much for Arizona, marking a definitive statement from the 49ers this season.