In a commanding display, the New England Patriots triumphed over the Buffalo Bills with a final score of 49-17 in Week 4 of the 2026 season. The Patriots, looking to solidify their position in the standings, dominated the game from start to finish, showcasing their offensive firepower. Drake Maye led the charge for New England, throwing for an impressive 398 yards and six touchdowns, making it a night to remember for the young quarterback. Complementing his performance, TreVeyon Henderson added 88 rushing yards, while Romeo Doubs emerged as a favorite target, racking up 171 receiving yards. The offensive onslaught left the Bills struggling to respond throughout the contest. The Patriots' defense played a crucial role, with Kevin Byard III recording two interceptions that shifted the momentum firmly in New England's favor. As the Bills attempted to mount a comeback, Byard's second pick late in the third quarter effectively sealed the game, showcasing the Patriots' ability to capitalize on opportunities. With consistent pressure and key turnovers, New England's defense ensured that the Bills remained firmly in check.