The San Francisco 49ers secured a pivotal victory over the Arizona Cardinals, winning 41-28 in Week 16 of the 2027 season. With playoff implications on the line, the 49ers delivered a strong performance that keeps their postseason hopes alive while pushing the Cardinals closer to elimination. Tyler Shough led the charge for San Francisco, throwing for 261 yards and providing a steady hand in the pocket. Breece Hall was a standout on the ground, racking up 139 rushing yards, while De'Zhaun Stribling was the primary target in the passing game, finishing with 89 receiving yards. Carson Beck responded for Arizona with two touchdown passes, but it wasn't enough to keep pace with the 49ers' offensive assault. Defensively, the 49ers made their mark with Harrison Smith's two interceptions, showcasing a knack for capitalizing on mistakes. Xavier Lucas anchored the defense with four total tackles, helping to stifle any late-game surges from the Cardinals. The turning point came in the fourth quarter when Smith's second interception set up a critical touchdown drive, allowing San Francisco to pull away and ultimately seal the victory.