In a high-octane showdown, the San Francisco 49ers outlasted the Arizona Cardinals with a final score of 59-41. This Week 3 matchup of the 2026 season showcased two explosive offenses, but the 49ers ultimately secured the win, giving them a strong start to the year. Brock Purdy was phenomenal under center for San Francisco, throwing for an impressive 427 yards and leading the charge with pinpoint accuracy. Christian McCaffrey was a dual-threat nightmare, amassing 151 rushing yards and racking up 266 receiving yards, making him the focal point of the 49ers' offensive onslaught. Meanwhile, Shedeur Sanders kept the Cardinals competitive with five touchdown passes, but it wasn't enough to keep pace with San Francisco's firepower. On the defensive side, the 49ers made critical plays to disrupt the Cardinals' rhythm, with Dre Greenlaw recording a sack and Renardo Green snagging an interception. The game's turning point came late in the third quarter when Green's interception shifted momentum back to the 49ers, allowing them to extend their lead and ultimately seal the victory. The Cardinals fought valiantly, but San Francisco's balanced attack and timely defensive stops made the difference in this thrilling contest.