In a thrilling Week 3 showdown, the San Francisco 49ers defeated the Arizona Cardinals 42-28, marking a crucial win for the 49ers in their pursuit of a strong season. This matchup showcased the offensive firepower of San Francisco, who came into the game looking to establish themselves early in the 2026 season. Tyler Shough was the star of the day, throwing for an impressive 364 yards and three touchdowns, leading his team with precision and poise. Complementing his performance was Christian McCaffrey, who dominated on the ground with 128 rushing yards, consistently moving the chains. Ricky Pearsall also had a standout game, racking up 158 receiving yards, providing Shough with a reliable target throughout the contest. Defensively, the 49ers made their mark with Fred Warner's remarkable 2.5 sacks, disrupting the Cardinals' offensive rhythm. Ji'Ayir Brown's two interceptions were pivotal, swinging momentum in San Francisco's favor and ultimately sealing the victory. The game's turning point came late in the second quarter when Brown's second pick led to a quick touchdown, giving the 49ers a comfortable lead they would not relinquish.