In a dominating performance, the Seattle Seahawks routed the San Francisco 49ers 41-0 in Week 1 of the 2027 season. The Seahawks showcased their offensive firepower and set a strong tone for the season, while the 49ers struggled to find their footing from the outset. Seattle's Sam Darnold was the standout performer, throwing for an impressive 414 yards and five touchdowns, leading the way for his team. Jaxon Smith-Njigba also had a remarkable game, racking up 178 receiving yards, making critical catches that kept the 49ers' defense on their heels. Christian McCaffrey managed just 47 rushing yards for San Francisco, as the 49ers were unable to establish a ground game. The Seahawks' defense played a crucial role in the blowout victory, shutting out the 49ers and forcing them into tough situations throughout the contest. Bud Clark led the defense with five tackles, while Derick Hall added a sack, putting pressure on the 49ers’ offense. The game’s turning point came early in the second quarter when Jessie Bates III intercepted a pass, setting up another touchdown for Seattle and effectively sealing the game.