In a commanding performance, the San Francisco 49ers topped the Arizona Cardinals 50-21 in Week 3 of the 2026 season. This victory not only solidifies the 49ers' place in the standings but also showcases their offensive firepower as they look to establish dominance early in the season. Brock Purdy was nothing short of spectacular, throwing for 376 yards and an impressive six touchdown passes, leading the charge for San Francisco's high-octane offense. Christian McCaffrey added a solid ground game with 80 rushing yards, while Jordan Watkins emerged as a key target, racking up 110 receiving yards. The 49ers' offensive efficiency was evident as they consistently moved the ball and found the end zone. Defensively, the 49ers made their presence felt, with Darrick Forrest leading the team with four total tackles. The turning point came when Marques Sigle intercepted a pass, shifting momentum firmly in San Francisco's favor. Dre Greenlaw also contributed with a sack, helping to keep pressure on the Cardinals' offense and ensuring the 49ers maintained control throughout the game.