The Los Angeles Rams secured a commanding victory over the Arizona Cardinals with a final score of 49-21 in Week 10 of the 2026 season. This game was crucial for both teams as they battle for playoff positioning, but the Rams showcased their dominance on both sides of the ball. Matthew Stafford was the standout performer, throwing for 316 yards and four touchdowns, while Kyren Williams added a stellar 136 rushing yards to keep the Cardinals' defense off balance. Puka Nacua was a key target, racking up 170 receiving yards and contributing significantly to the Rams' high-scoring effort. On the defensive side, Aaron Donald made his presence felt with two sacks, disrupting Arizona's offensive rhythm. The turning point came late in the second quarter when Jaylen Watson intercepted a pass, leading to another Rams touchdown and pushing the lead to an insurmountable margin. The Rams' defense, coupled with their explosive offense, ultimately sealed the game and maintained their momentum heading into the final stretch of the season.