In a commanding display, the Buffalo Bills topped the New England Patriots 45-13 in Week 4 of the 2026 season. This victory solidifies the Bills’ position as a formidable contender in the league, while the Patriots struggle to find their footing early in the season. Josh Allen led the charge for Buffalo with two touchdown passes, showcasing his ability to stretch the field. Meanwhile, James Cook III was a force on the ground, racking up an impressive 176 rushing yards, consistently breaking through tackles and keeping the Patriots' defense on their heels. For New England, Drake Maye threw for 219 yards but struggled to find the end zone, with A.J. Brown leading the receiving corps with 96 yards. Defensively, the Bills were relentless, with Greg Rousseau making a significant impact, not only recording seven tackles but also dominating with six sacks against Maye. The game’s turning point came in the second quarter when Rousseau’s pressure led to an interception by Cole Bishop, setting up a short touchdown drive that shifted momentum firmly in Buffalo's favor. The Bills' defense proved they can create turnovers and apply consistent pressure, a combination that will be crucial as the season progresses.