In a commanding display, the Denver Broncos toppled the San Francisco 49ers with a final score of 42-10 in Week 4 of the 2026 season. The win not only boosts Denver's standings but also sends a strong message about their offensive firepower and defensive resilience as they aim for a playoff run. The Broncos' offense was led by quarterback Bo Nix, who threw for three touchdowns and showcased his efficiency throughout the game. Running back J.K. Dobbins added a stellar performance with 110 rushing yards, while wide receiver Jaylen Waddle contributed significantly with 90 receiving yards, making crucial plays that kept the chains moving for Denver. Defensively, the Broncos made their presence felt with standout performances, particularly from Justin Strnad, who secured an interception that shifted momentum in Denver's favor. The turning point came in the second quarter when Strnad's pick set up a quick scoring drive, allowing the Broncos to pull away and never look back. Despite Nick Bosa's two sacks for San Francisco, the Broncos' relentless offensive assault proved too much to handle.