The San Francisco 49ers cruised to a convincing 42-21 victory over the Seattle Seahawks in Week 5 of the 2026 season. With this win, the 49ers solidify their position as a formidable contender in the playoff race, while the Seahawks will need to regroup after a tough home loss. Brock Purdy delivered a standout performance, throwing for 276 yards and three touchdowns, effectively leading the 49ers' high-octane offense. Christian McCaffrey contributed significantly on the ground, adding 73 rushing yards, while Mike Evans was a standout in the passing game, racking up 133 receiving yards. Together, they showcased the offensive firepower that has become a hallmark of San Francisco's game plan this season. Defensively, Fred Warner was a game-changer for the 49ers, snagging two interceptions that shifted momentum in their favor. Deommodore Lenoir led the team in tackles with four, helping to stifle the Seahawks' attempts to mount a comeback. The turning point came when Warner's second interception set up a quick touchdown, extending the 49ers' lead and putting the game out of reach for Seattle.