In a tightly contested matchup, the Buffalo Bills narrowly defeated the Los Angeles Chargers 25-22 in Week 3 of the 2026 season. Both teams were looking to solidify their positions early in the season, but it was the Bills who came out on top in this thrilling encounter. Josh Allen led the way for Buffalo with 209 passing yards, finding his favorite target DJ Moore, who racked up 97 receiving yards. On the other side, Justin Herbert showcased his prowess with two touchdown passes, while Omarion Hampton was the standout on the ground for the Chargers, accumulating 82 rushing yards. Defensively, the Bills made crucial plays to secure the victory, with Terrel Bernard leading the charge with 10 total tackles. Ed Oliver was also a force, notching 1.5 sacks that helped disrupt the Chargers' offensive rhythm. The turning point came late in the fourth quarter when Buffalo’s defense held strong, forcing a turnover on downs that sealed the win for the Bills.