In a commanding performance, the San Francisco 49ers topped the Los Angeles Chargers 38-10 in Week 15 of the 2026 season. With playoff implications on the line, the 49ers solidified their position as a top contender, displaying a dominant offensive and defensive effort throughout the game. Brock Purdy led the charge for San Francisco, throwing for 250 yards and connecting on four touchdown passes, showcasing his precision and poise under pressure. Christian McCaffrey complemented the aerial attack with a strong ground game, racking up 106 rushing yards, while De'Zhaun Stribling added 80 receiving yards to keep the chains moving and the Chargers' defense on its heels. Defensively, the 49ers were relentless, with Nick Bosa recording two crucial sacks that disrupted the Chargers' rhythm. Jack Jones sealed the game with an interception, exemplifying San Francisco's ability to capitalize on mistakes. The turning point came early in the second half when the 49ers scored back-to-back touchdowns, effectively putting the game out of reach for the Chargers.