In a tightly contested matchup, the San Francisco 49ers topped the Seattle Seahawks 21-14 in Week 5 of the 2026 season. The victory keeps the 49ers firmly in the playoff picture, while the Seahawks will be left searching for answers as they look to rebound in the coming weeks. Jalen Milroe of the Seahawks put on a strong performance, throwing for 254 yards and two touchdowns, showcasing his ability to connect with his receivers, including Tory Horton, who racked up 146 receiving yards. However, it was Christian McCaffrey who stole the spotlight for the 49ers, rushing for 122 yards and providing a crucial balance to San Francisco's offensive attack. Defensively, the 49ers made key plays that shifted the momentum in their favor. Nick Bosa was a force up front, recording 3.5 sacks, while Fred Warner secured an interception that halted a potential Seahawks scoring drive, marking a pivotal moment in the contest. San Francisco's defense held strong when it mattered most, ultimately sealing the victory and reinforcing their status as a contender.