In a decisive Week 18 showdown, the Arizona Cardinals topped the San Francisco 49ers with a final score of 24-10, solidifying their playoff positioning as the regular season comes to a close. The Cardinals showcased their offensive prowess, while the 49ers struggled to find their rhythm on both sides of the ball. Quarterback Joe Milton led the charge for Arizona, throwing for an impressive 310 yards and a touchdown. His favorite target, Dont'e Thornton Jr., made a significant impact with 114 receiving yards, consistently moving the chains and providing crucial plays. Despite a strong performance from Christian McCaffrey, who rushed for 75 yards, the 49ers couldn't match Arizona's offensive firepower. Defensively, the Cardinals were relentless, highlighted by a key interception from Budda Baker that shifted momentum in their favor. Chris Braswell added pressure with a sack, disrupting the 49ers' offensive plans. The turning point came early in the second half when Baker's interception set up a touchdown drive, putting the Cardinals ahead and forcing San Francisco to play catch-up for the remainder of the game.