In a dominating performance, the Arizona Cardinals defeated the Detroit Lions 56-10 in Week 5 of the 2026 season. With this victory, the Cardinals continue to solidify their position as one of the top teams in the league, while the Lions struggle to find their footing as the season progresses. Cardinals quarterback Joe Milton had a standout game, throwing for an impressive 502 yards and six touchdowns. The passing attack was bolstered by Dont'e Thornton Jr., who racked up 193 receiving yards, proving to be a reliable target throughout the contest. Jahmyr Gibbs was the lone bright spot for the Lions, rushing for 101 yards, but it was not enough to keep pace with Arizona's offensive firepower. Defensively, the Cardinals were equally impressive, with Budda Baker leading the charge with seven total tackles and two crucial interceptions that shifted the momentum decisively in Arizona's favor. The turning point came late in the first half when Baker's second interception set up another quick touchdown for the Cardinals, extending their lead to 35-10 and effectively sealing the game. Kaleb Proctor added to the defensive effort with a sack, further frustrating the Lions' offensive rhythm.