The Houston Texans dominated the Indianapolis Colts with a final score of 42-21, showcasing their offensive prowess in Week 3 of the 2026 season. This matchup was crucial for both teams as they aimed to establish early-season momentum, but the Texans proved too strong on the road. C.J. Stroud led the charge for Houston, throwing for 282 yards and an impressive five touchdowns, demonstrating his rising star status in the league. Meanwhile, Mike Washington Jr. made his mark on the ground, racking up 171 rushing yards that kept the Colts' defense on its heels throughout the game. Together, their performances were instrumental in propelling the Texans to a comfortable victory. Defensively, the Texans were relentless, with Will Anderson Jr. recording three sacks and Azeez Al-Shaair intercepting four passes, creating pivotal turnovers that shifted the game's momentum. The turning point came in the second quarter when Al-Shaair's interception set up a touchdown that extended the lead to 21-7, leaving the Colts struggling to catch up. Overall, the Texans' defensive efforts were key in sealing the win and stifling any hopes of a Colts comeback.