In a dominating performance, the Buffalo Bills defeated the Detroit Lions 91-20 in Week 2 of the 2026 season. The Bills showcased their offensive prowess, as they aimed to establish early momentum in the league, while the Lions struggled to keep pace throughout the game. Quarterback Josh Allen was nothing short of sensational, amassing an astounding 743 passing yards and tossing 11 touchdown passes. His favorite target, James Cook III, racked up 194 receiving yards, proving to be a consistent threat down the field. The Lions' Isiah Pacheco contributed with a modest 64 rushing yards, but it was clear that the Bills' air attack was the story of the night. On the defensive side, the Bills' Cole Bishop made a significant impact with two key interceptions, halting any potential momentum from the Lions. Despite a solid defensive effort from D.J. Reed, who recorded six total tackles for Detroit, the turning point came early in the second quarter when Allen threw three consecutive touchdown passes. This barrage put the game out of reach and set the tone for a commanding victory.