In a thrilling Week 1 matchup, the Buffalo Bills topped the San Francisco 49ers with a final score of 31-21, kicking off the 2028 season with a statement victory. Both teams showcased their offensive firepower, but the Bills ultimately held off a late surge from the 49ers to secure the win. Josh Allen led the Bills' charge, throwing for an impressive 312 yards and contributing significantly to their scoring efforts. Brock Purdy of the 49ers kept pace with three touchdown passes, while Ricky Pearsall emerged as a standout receiver, racking up 171 yards. Jordan James also made an impact on the ground for San Francisco, rushing for 61 yards. Defensively, the Bills made crucial plays that altered the game's momentum. T.J. Sanders recorded a sack, while Maxwell Hairston came up with a key interception, halting a potential scoring drive for the 49ers. The turning point came late in the game when Hairston picked off Purdy, preserving the Bills' lead and allowing Buffalo to run out the clock for the win.