The Arizona Cardinals topped the San Francisco 49ers with a final score of 24-16, securing a crucial win in Week 13 of the 2028 season. With both teams vying for playoff positioning, this victory keeps the Cardinals in the hunt as they look to solidify their standing in a competitive conference. Kyler Murray led the Cardinals’ offense, throwing for 207 yards and showcasing his ability to make key plays when it mattered most. Although Brock Purdy of the 49ers threw two touchdown passes, it was not enough to overcome the Cardinals' balanced attack. Jordan James added a solid ground game for San Francisco with 71 rushing yards, while Ricky Pearsall was a reliable target, racking up 93 receiving yards. Defensively, the Cardinals stepped up when it counted, with DeMarvion Overshown leading the charge with six total tackles. Walter Nolen contributed with a critical sack, applying pressure on Purdy that disrupted the 49ers' offensive rhythm. The turning point came in the fourth quarter when the Cardinals' defense stifled a potential game-tying drive, forcing a turnover on downs that ultimately sealed the victory.