In a tightly contested battle, the Denver Broncos topped the San Francisco 49ers with a final score of 14-6, securing a critical victory in Week 4 of the 2026 season. Both teams were looking to establish momentum, but it was the Broncos who ultimately emerged victorious on the road. Leading the charge for Denver was quarterback Joe Milton, who threw for 177 yards and two touchdowns, showcasing his skill under pressure. Tyler Harrell was a standout in the receiving game, racking up 92 yards and providing a reliable target for Milton. Meanwhile, Christian McCaffrey led the 49ers' ground attack with 68 rushing yards, but it wasn't enough to overcome the Broncos' offensive efforts. Defensively, Denver's performance was pivotal in the outcome, with Nik Bonitto leading the charge with two sacks and two total tackles. Brandon Jones added a crucial interception, further disrupting San Francisco's offensive rhythm. The game's turning point came in the second half when Jones picked off a pass, allowing the Broncos to extend their lead and ultimately secure the win.