In a decisive matchup, the Tennessee Titans topped the San Francisco 49ers with a final score of 35-20, marking a strong start to their 2027 season. The Titans aimed to establish themselves as early contenders, while the 49ers sought to bounce back after a rocky opener. On the offensive side, Tennessee’s Isaac Brown was the star of the night, rushing for an impressive 138 yards and contributing significantly to the Titans' ground game. San Francisco's Brock Purdy put up a valiant effort, throwing for 242 yards and two touchdowns, but it wasn't enough to keep pace with the Titans’ relentless attack. De’Zhaun Stribling also shined for the 49ers, racking up 102 receiving yards, showcasing his ability to stretch the field. Defensively, the Titans made pivotal plays that shifted momentum in their favor, particularly C.J. Gardner-Johnson, who snagged an interception to halt a promising 49ers drive. San Francisco's Gracen Halton was a standout with four total tackles and a sack, but his efforts were not enough to contain Tennessee’s explosive offense. The turning point came in the second quarter when the Titans scored two quick touchdowns to pull ahead, a lead they would not relinquish for the remainder of the game.