In a decisive Week 2 matchup, the San Francisco 49ers topped the Miami Dolphins with a final score of 44-20, solidifying their early-season dominance. The 49ers looked to make a statement as they kicked off their journey with a powerful performance against a Dolphins team eager to prove themselves in the 2026 season. Quarterback Joe Burrow led the charge for San Francisco, throwing for two touchdowns while efficiently managing the game. James Cook III was a standout on the ground, racking up 97 rushing yards, and his explosive runs helped maintain momentum. Miami's Kyler Murray put up solid numbers with 249 passing yards, while Justin Jefferson showcased his skills with 104 receiving yards, but the Dolphins struggled to keep pace. Defensively, the 49ers were impactful, highlighted by Dorance Armstrong's sack and interception, which shifted the game’s momentum. San Francisco’s defense not only applied consistent pressure but also capitalized on key mistakes, proving to be the turning point in this contest. As the game progressed, the 49ers' ability to disrupt Miami’s rhythm ultimately sealed their victory.