The San Francisco 49ers dominated the Arizona Cardinals with a final score of 42-10, showcasing their power in Week 2 of the 2027 season. With this victory, the 49ers aim to solidify their position as a top contender early in the season, while the Cardinals will need to regroup after a tough outing at home. Harry Calls Jr. led the charge for San Francisco, throwing for three touchdowns and establishing a strong rhythm in the passing game. Jalen Hurts of the Cardinals put up impressive numbers with 346 passing yards, but the lack of scoring support left Arizona struggling to keep pace. Meanwhile, Drake London emerged as a bright spot for the Cardinals, racking up 260 receiving yards in a losing effort. Defensively, the 49ers made crucial plays that shifted momentum in their favor, highlighted by Mike Sainristil's interception that halted a potential scoring drive for Arizona. Ryan Shazier Jr. anchored the defense with four total tackles, helping to keep the Cardinals' offense off-balance throughout the game. The turning point came in the second quarter when San Francisco scored back-to-back touchdowns, effectively sealing their commanding lead and leaving Arizona with no chance to recover.