In a dominant display, the San Francisco 49ers topped the Arizona Cardinals 42-14 in Week 3 of the 2026 season. This victory not only boosts the 49ers' confidence but also solidifies their standing as a formidable force early in the year, showcasing their offensive prowess and defensive strength. Leading the charge for San Francisco was quarterback Brock Purdy, who threw for an impressive 355 yards and four touchdowns, demonstrating pinpoint accuracy and poise under pressure. Wide receiver Mike Evans was a standout target, racking up 200 receiving yards, while Christian McCaffrey added a solid ground game with 89 rushing yards, contributing to a well-rounded offensive effort. On the defensive side, Deommodore Lenoir led the team with seven total tackles, but it was Nick Bosa's two sacks that really helped disrupt Arizona's rhythm. The game's turning point came when Fred Warner intercepted a pass, halting a potential scoring drive and allowing the 49ers to extend their lead. With both sides of the ball performing at a high level, San Francisco proved to be a tough opponent for any team looking to compete this season.