In a stunning display of dominance, the Arizona Cardinals crushed the San Francisco 49ers with a final score of 62-0 in Week 3 of the 2026 season. This victory not only showcased the Cardinals' offensive firepower but also served as a stark reminder of the challenges facing the 49ers as they seek to find their footing this season. Leading the charge for Arizona was Joe Milton, who put on a passing clinic with an impressive 505 yards and eight touchdown passes. Omari Evans was his favorite target, racking up 251 receiving yards, making it nearly impossible for the 49ers' defense to keep pace. The Cardinals' offensive efficiency left little doubt, as they found the end zone time and time again. On the defensive side, Jailin Walker spearheaded the Cardinals' effort with five total tackles, helping to stifle any offensive momentum from the 49ers. The turning point came early in the game when a critical turnover led to a quick touchdown for Arizona, setting the tone for a one-sided affair. With San Francisco unable to respond, the Cardinals took full advantage, solidifying their position as a formidable contender this season.