In a commanding performance, the San Francisco 49ers topped the Los Angeles Chargers 37-14 in Week 15 of the 2026 season. With playoff positioning on the line, the 49ers showcased their offensive prowess and solidified their standing in the league. Brock Purdy led the charge for San Francisco, throwing for 276 yards and four touchdowns, putting on a display of accuracy and poise. He connected frequently with George Pickens, who racked up 117 receiving yards, while Javonte Williams added a steady ground game with 66 rushing yards to keep the chains moving. Defensively, the 49ers were relentless, with Osa Odighizuwa recording 1.5 sacks and Fred Warner making a significant impact with two interceptions, stifling any Chargers hopes of a comeback. The game turned decisively in the second quarter when Warner's second pick set up a quick touchdown, giving the 49ers a comfortable lead they would not relinquish.