In a commanding performance, the Kansas City Chiefs topped the San Francisco 49ers 46-3 in Week 16 of the 2026 season. With playoff implications on the line, the Chiefs solidified their position as one of the league's top contenders, showcasing a dominant offense and tenacious defense throughout the game. Chiefs quarterback Patrick Mahomes was nothing short of spectacular, throwing for 350 yards and four touchdowns, effectively dictating the pace of the game. Wide receiver Xavier Worthy was his favorite target, racking up 138 receiving yards and finding the end zone, while Kenneth Walker's 78 rushing yards added balance to the offensive onslaught. Defensively, the Chiefs were relentless, highlighted by George Karlaftis' sack and Chamarri Conner's interception, both crucial in stifling any hope for a San Francisco comeback. The turning point came early in the second half when Mahomes connected with Worthy for a touchdown, extending the lead to 30-3 and effectively putting the game out of reach for the 49ers.