In a commanding performance, the Los Angeles Rams topped the San Francisco 49ers with a final score of 65-28 in Week 2 of the 2027 season. This decisive victory not only boosts the Rams' confidence but also sets the tone for their campaign as they look to establish dominance in the division. Quarterback Matthew Stafford showcased an explosive passing attack, throwing for 327 yards and an astonishing seven touchdowns, leading the Rams' offensive onslaught. Puka Nacua was his favorite target, racking up 153 receiving yards and contributing significantly to the scoreline. Despite a modest ground game, with Kyren Williams managing just 33 rushing yards, the aerial assault left the 49ers' defense reeling. Defensively, the Rams were equally impressive, with Myles Garrett notching 1.5 sacks and Leonard Moore grabbing two interceptions to stifle any momentum from San Francisco. The game's turning point came in the second quarter when Stafford connected with Nacua for a long touchdown that shifted the momentum entirely in favor of the Rams. With their defense creating turnovers and pressure, Los Angeles maintained control throughout, ensuring a statement win over their rivals.