In a dominating performance, the Denver Broncos defeated the San Francisco 49ers with a final score of 46-15 in Week 4 of the 2026 season. This victory solidified the Broncos' standing as a formidable contender, showcasing their offensive firepower while leaving the 49ers struggling to find their rhythm. Broncos quarterback Bo Nix was the star of the game, throwing for 373 yards and an impressive five touchdowns. His connection with the receivers proved lethal, as the Broncos consistently moved the ball downfield with precision. Meanwhile, San Francisco's Christian McCaffrey struggled to find running room, managing only 25 rushing yards, while KaVontae Turpin led the 49ers in receiving with 149 yards, but it wasn't enough to keep pace with Denver's explosive offense. Defensively, the Broncos were relentless, with Trevin Wallace leading the team with four total tackles, while Zach Allen recorded two sacks to disrupt the 49ers' offensive flow. Dillon Thieneman made a significant impact with two interceptions, contributing to a turning point in the game that shifted momentum firmly in Denver's favor. The Broncos' defense not only held San Francisco to a mere 15 points but also created crucial turnovers that helped secure the commanding victory.