In a decisive start to the 2027 season, the San Francisco 49ers topped the Arizona Cardinals 24-6. With both teams looking to make an early statement, the 49ers showed their dominance on both sides of the ball, setting the tone for their campaign ahead. Offensively, Christian McCaffrey was the standout performer for San Francisco, rushing for 109 yards and consistently moving the chains. Quarterback Carson Beck of the Cardinals put up a respectable 239 passing yards but struggled to convert those yards into points, with the 49ers' defense proving to be too formidable. Ricky Pearsall contributed with 60 receiving yards, helping San Francisco maintain their lead throughout the game. Defensively, the 49ers were relentless, led by Deommodore Lenoir, who recorded eight tackles and an interception, making critical plays that halted Arizona's momentum. Nick Bosa was a game-wrecker, notching 3.5 sacks and applying constant pressure on Beck, forcing him into tough situations. The turning point came in the second quarter when Lenoir's interception set up a touchdown drive, giving the 49ers a commanding lead they would not relinquish.