In a tightly contested matchup, the Arizona Cardinals topped the San Francisco 49ers with a final score of 21-13, marking a crucial victory in Week 3 of the 2027 season. Both teams entered the game looking to solidify their standings early in the season, but it was the Cardinals who ultimately came out on top. Offensively, Brock Purdy of the 49ers threw for 260 yards and secured two touchdowns, showcasing his ability to lead the team despite the loss. On the ground, Jeremiyah Love was a force for the Cardinals, racking up 87 rushing yards and providing a steady presence in the backfield. Meanwhile, Ricky Pearsall was a standout in the passing game for San Francisco, accumulating 113 receiving yards and keeping the 49ers in striking distance. Defensively, Mack Wilson Sr. was a key player for Arizona, recording four tackles and a critical sack that disrupted the 49ers’ momentum. The turning point came in the second half when Wilson’s sack led to a turnover on downs, allowing the Cardinals to maintain their lead and ultimately secure the win. Despite a strong showing from San Francisco's defense, including an interception from Jamel Johnson, it was the Cardinals' timely defensive plays that made the difference.