The San Francisco 49ers kicked off the 2027 season with a commanding 38-16 victory over the Arizona Cardinals. This matchup was critical for both teams as they aimed to establish an early foothold in the competitive NFC West. With this win, the 49ers set a strong tone for their season ahead. Brock Purdy was the standout performer for San Francisco, throwing for 341 yards and three touchdowns, showcasing his ability to command the offense. De'Zhaun Stribling emerged as his primary target, racking up an impressive 191 receiving yards, making key plays that helped keep the chains moving. Christian McCaffrey contributed on the ground with 56 rushing yards, supporting the balanced offensive attack. Defensively, the 49ers were relentless, with Sean Murphy-Bunting leading the charge with seven total tackles, providing crucial stops throughout the game. The turning point came in the second quarter when the 49ers forced a turnover that led to a quick touchdown, allowing them to pull away from the Cardinals. Although the Cardinals did have some pressure from White Weeks, who notched half a sack, it wasn’t enough to stifle San Francisco's offensive rhythm.