In a dominant display, the San Francisco 49ers topped the Arizona Cardinals 51-14 in Week 3 of the 2026 season. This victory not only boosts the 49ers' confidence but also solidifies their position as a formidable force in the league early in the season. Brock Purdy led the charge for San Francisco, throwing for 283 yards and four touchdowns, showcasing his impressive arm and decision-making. Meanwhile, Christian McCaffrey was a force on the ground, racking up 160 rushing yards, while De'Zhaun Stribling torched the Cardinals' secondary with 182 receiving yards. Together, they formed an explosive offensive trio that overwhelmed Arizona throughout the game. Defensively, the 49ers were relentless, with Marlon Humphrey leading the way with nine total tackles. Nick Bosa added to the pressure with 1.5 sacks, making life difficult for the Cardinals' offense. The pivotal moment came with Fred Warner's two interceptions, which shifted the momentum firmly in San Francisco's favor and sealed the game well before the final whistle.